Nucleic Acid Isolation & Purification Market Size, Growth, and Industry Outlook 2023-2030 | DataM Intelligence
Market Overview:
The global nucleic acid isolation & purification market is a vibrant and booming sector of the overall biotechnology industry. Nucleic acid sample preparation entails a variety of processes used to convert a sample that cannot be directly analysed into one that meets the requirements of the analytical technique being employed, such as reverse transcription (RT) or PCR. Purification and quality evaluation of nucleic acid samples are critical processes in experimental workflows because the quality of nucleic acids might impact the efficiency of subsequent operations.
The nucleic acid isolation process employs mechanical and chemical disruption, as well as enzymatic digestion, whereas the purifying phase employs extraction/precipitation, chromatography, centrifugation, electrophoresis, and affinity separation. This method has several uses in genetic engineering, life science research, forensics, molecular diagnostics, and diagnostic testing for STDs, congenital abnormalities, and cancer research.
Market Size Growth Rate:
According to the DataM market research report, the global nucleic acid isolation & purification market size is valued at USD 5.3 billion in 2022, it is expected to reach USD 9.2 billion by 2030, with growth at a CAGR of 7.4% over the forecast period 2023-2030. North America is estimated to contribute 38.6% to the growth of the global market over the forecast period.
The global nucleic acid isolation & purification market is driven by factors like advancements in molecular diagnostics, increasing the prevalence of genetic disorders, cancer, infectious diseases, and STDs, a rise in investments by key players for research, and rising healthcare expenditures. On the other hand, the high cost of automated instruments, lack of skilled professionals, low market penetration, and shift from proteomics to genomics are going to restrain the market in the forecast period.
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Market Drivers:
The rise in the prevalence of Sexually Transmitted Diseases (STDs) is one of the key factors that drive the nucleic acid isolation & purification market to grow during the forecast period. STDs are often caused by bacteria, viruses, and other microbes that contain nucleic acid (DNA & RNA), and nucleic acid isolation and purification help in the extraction of genetic material from patient specimens utilizing various procedures.
For instance, according to the Minnesota Department of Health (MDH) updated factsheet 2023, there were 32,072 STD cases reported in 2022 compared to 33,706 cases in 2021, a 5% decrease. Chlamydia one of the forms of STD remained the number one reported STD in the state with 22,079 cases reported, a 2% decrease compared to 22,578 in 2021.
Thus, a rise in investments by key players is also a major factor that drives the market during the forecast period. For instance, in April 2022, Zymo Research and Star Array acquired an interest in Singapore-based biomedical technology company Star Array. The strategic investment enables Zymo Research to combine nucleic acid purification and assay technologies with Star Array’s engineering and automation expertise, expanding into FRUO and diagnostic markets, including Point-of-Care testing.
Market Restraints:
The expensive nature of automated instrumentation is predicted to limit the industry of nucleic acid isolation and purification. Traditional processes are more expensive than kits and automated instruments for nucleic acid isolation and purification. Automated instruments provide significant benefits such as easier separation methods, shorter work hours, increased safety, and improved throughput. However, the costly expense of this equipment prohibits it from being widely used.
NAIP automated instruments range in price from USD 8,000 to USD 160,000. Additional expenditures for reagents, disposables, maintenance, and training are incurred by these devices. This expensive equipment is out of reach for institutes and firms with limited research and development resources. Additionally, a lack of qualified staff and system contamination are concerns that will hamper market expansion throughout the projection period.
Market Opportunities:
The rise of personalized medicine and genomics has significant opportunities in the nucleic acid isolation and purification industry. The high growing demand for high-quality nucleic acids creates the opportunity for the companies to research and develop effective extraction solutions from various sample types which can explore genomics research and therapeutic applications in industry which indeed creates an opportunity for the market in future.
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COVID-19 Impact Analysis:
COVID-19 had a substantial influence on market growth throughout the pandemic era. This was mostly due to a huge rise in illness diagnostics and medication research. During the pandemic, the need for nucleic acid and purification increased due to studies into the dynamics of the SARS-CoV-2 virus and COVID-19 infection.
Apart from that, the COVID-19 pandemic has had a substantial influence on global civilization, prompting urgent worldwide SARS-CoV-2 testing. The most common reference test uses PCR-based amplification, utilising commercial solid-phase RNA extraction kits as the starting point. However, the global demand for these kits has limited their availability, prompting the development of alternate approaches such as organic solvent-based extraction and chaotropic compounds.
Russia-Ukraine War Impact Analysis:
The war between Russia and Ukraine has had a substantial impact on the nucleic acid isolation and purification industry, as these countries are important producers of reagents and consumables. Although, this has disrupted supply chains and increased prices, leading to a surge in demand for nucleic acid isolation kits for COVID-19 and other diagnostic tests. Overall, the impact was high on the import and export of kits which had a significant influence on the global nucleic acid isolation & purification market growth over the forecast period.
Recent Developments in the Industry:
- In May 2023, One BioMed, announced the launch of the X8 HMW DNA Cartridge Kits for the automated extraction of high molecular weight DNA for use in long-read sequencing and genome assembly.
- In April 2023, PacBio, a leading sequencing solution developer, released high-throughput Nanobind DNA Extraction kits. These kits enable researchers to extract high-quality DNA from various samples in a high-throughput setting, using a simple protocol compatible with automation platforms.
- In October 2022, Thermo Fisher Scientific invested USD 97 million in Richmond, Virginia, to expand its clinical research activities. This laboratory will offer high-quality bioanalytical lab services to help clinical research programmes move forward.
- In May 2022 Qiagen Inc. launched the NeuMoDxHSV 1/2 Quant Assay, enabling the quantification and differentiation of herpes simplex virus type 1 and/or type 2 DNA. With European Commission approval, this innovative test expands Qiagen’s laboratory testing portfolio, contributing to market growth.
Market Segmentation:
As per the research analysis, the global nucleic acid isolation & purification market is segmented by product type (DNA & RNA Extraction Kits, Reagents, Instruments), by technology(Reagent-Based Isolation and Purification, Column-Based Isolation and Purification, Magnetic Bead-Based Isolation and Purification, Other Technologies) by application (Diagnostics, Precision Medicine, Drug Discovery and Development, Other Applications), by end-user (Hospitals and Diagnostic Centers, Academic and Government Research Institutes, Pharmaceutical and Biotechnology Companies, Contract Research Organizations and Others).
- Based on product type, the DNA & RNA extraction kits segment is estimated to contribute 36.9% to the growth of the global market over the forecast period (2023-2030). Low-cost, easy to use and applications in gene sequencing, molecular diagnostics, and gene cloning are going to fuel the kits market.
For instance, in March 2023, BioEcho launched EchoLUTION FFPE DNA Kit for a simplified DNA extraction from FFPE samples DNA extraction from formalin-fixed paraffin-embedded (FFPE) tissues are an essential step when performing downstream applications used in drug development, biomarker investigation, pathology, as well as in clinical diagnostics and cancer research.
- Based on technology, Magnetic Bead-Based Isolation and Purification segment is estimated to contribute 32.8% to the growth of the global market over the forecast period (2023-2030). This approach employs magnetic beads to selectively bind DNA in the presence of high salt concentrations. Magnetic-based technologies are suited for high-throughput processing automation because they eliminate the need for centrifugation and other time-consuming stages.
For instance, in June 2022, MGI Launched its First Magnetic Beads TQ01 to Support Cost-efficient Nucleic Acid Testing. As the normalized COVID-19 testing made the quality and cost control of the raw materials particularly important while ensuring the testing accuracy and stability, MGI launched its self-developed and mass-produced Magnetic Beads TQ01. This magnetic bead product is also the key raw material required for MGI’s widely used nucleic acid extraction reagent and MGIEasy Stool Human DNA extraction kit.
Geographical Classification:
The global nucleic acid isolation & purification market is segmented into major countries, including North America, Europe, South America, Asia Pacific, and Middle East & Africa.
North America Nucleic Acid Isolation & Purification Market:
The presence of agreements between key players, significant funding in biotechnology, technological advancements, better healthcare infrastructure and facilities, faster adoption of advanced technologies such as next-generation sequencing, and government support.
For instance, on July 2023, INOVIQ Limited, an innovative developer of exosome solutions and precision diagnostics, and Promega Corporation (Promega), a global leader in innovative technologies, tools and technical support to the life sciences industry, announced a joint marketing agreement to co-market INOVIQ’s EXO-NET exosome capture technology and Promega Nucleic Acid purification systems worldwide.
Asia-Pacific Nucleic Acid Isolation & Purification Market:
The Asia Pacific is slated to emerge as the fastest-growing regional market owing to rising healthcare expenditure, granting of patents, rapidly expanding economies, lower manufacturing costs, favourable government investments in the life sciences sector, and increasing government financing in research projects. Growing demand for quality healthcare is also an important factor in boosting the regional market.
Europe Nucleic Acid Isolation & Purification Market:
The market’s expansion is due to the presence of rising R&D expenditures, collaborations and agreements between the companies, growing company presence, and regional technological advancement helps this region to accelerate during the forecast period.
For instance, on February 20 2023, Bio Echo Life Sciences, a Germany-based biotechnology company, received two new patents for its EchoLUTION technology for nucleic acid extraction. The US and Japan Patent Offices issued the patents for “Rapid purification of high-quality nucleic acids from biological samples,” showcasing the company’s intellectual property portfolio and improving molecular biology protocols. EchoLUTION technology eliminates impurities and produces high-quality, inhibitor-free DNA or RNA for downstream applications, reducing the need for consumables and plastics.
Moreover, in September 2022, Purigen Biosystems, Inc., a leading provider of next-generation technologies for extracting and purifying nucleic acids from biological samples, announced a new distribution agreement with Proteigene. Under the terms of the agreement, Proteigene has received exclusive rights to distribute, service, and support Purigen’s automated Ionic Purification System and microfluidic kits in France.
Competitive Analysis:
There are numerous international, regional, and local suppliers in the global nucleic acid isolation & purification market. The competition in the local market is fierce. The vendors compete based on price, reagents and systems quality, and dependability. As a result, to prosper and survive in a competitive market, suppliers must provide cost-efficient and effective products.
Major Companies:
Major companies working towards the market’s growth include QIAGEN Inc, MP Biomedicals, Illumina, Inc, General Electric Company, Sigma-Aldrich, F.Hoffman-La Roche AG, Bio-Rad Laboratories, Promega Corporation, Danaher Corporation, Agilent Technologies, Thermo Fisher Scientific and among others
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The Full Report has the below insights:
- The report offers a comprehensive evaluation of the market in terms of market value (US) and Y-o-Y Growth Rates (%). It does so via in-depth qualitative insights, historical data (2021-2022), and verifiable projections about market size during the forecast period (2023-2030).
- Visualize the composition of the global nucleic acid isolation & purification market segmentation by mode, product, services, and region, highlighting the key commercial assets and players.
- By Product type: DNA & RNA Extraction Kits, Reagents, Instruments.
- By Technology: Reagent-Based Isolation and Purification, Column-Based Isolation and Purification, Magnetic Bead-Based Isolation and Purification, Other Technologies.
- By Application: Diagnostics, Precision Medicine, Drug Discovery and Development, Other Applications.
- By End User: Hospitals and Diagnostic Centers, Academic and Government Research Institutes, Pharmaceutical and Biotechnology Companies, Contract Research Organizations and Others.
- By Region: North America, South America, Europe, Asia Pacific, Middle East & Africa.
- Identify commercial opportunities in the global nucleic acid isolation & purification market by analyzing trends and co-development deals.
- The report also covers data insights on various industry forces such as Porter’s five forces analysis, supply chain analysis, pricing analysis, and regulatory analysis.
- Excel data sheet with thousands of data points of global nucleic acid isolation & purification market -level 4/5 segmentation.
- PDF report with the most relevant analysis cogently put together after exhaustive qualitative interviews and in-depth market study.
- Product mapping in Excel for the key product of all major market players
- The report will provide access to approximately 61 market data tables, 64 figures, and close to 180 pages.
DMI Opinion:
Overall, the global nucleic acid isolation & purification market will show significant growth in future as due to many factors like advancements in molecular diagnostics, increasing the prevalence of genetic disorders, cancer, infectious diseases, and STDs, a rise in investments by key players for research, and rising healthcare expenditures. Significantly the market has many obstacles which restrict the market growth the high cost of automated instruments, low market penetration, and shift from proteomics to genomics are going to restrain the market in the forecast period. However, the market has various opportunities in future in personalized medicine and genomics, rise in R&D investments, emerging markets etc.
Moreover, the market has a significant impact of covid 19 and other geographical events like Russia Ukraine war which indeed impact the overall growth of the market during the forecast period. The market has been segmented into 4 areas like product type, technology, application and end-user and the market has been having a different market share in various geographical regions like North America, Europe, Asia Pacific, South America, and the Middle East and Africa. Moreover, various key players involved in this market are QIAGEN Inc, MP Biomedicals, Illumina, Inc, General Electric Company, Sigma-Aldrich, F.Hoffman-La Roche AG, Bio-Rad Laboratories, Promega Corporation, Danaher Corporation, Agilent Technologies, Thermo Fisher Scientific and among others which dominates the overall market.
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