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Develop High-Quality Peptidomimetics With Creative Proteomics’ b-Amino Acids Analysis Solutions

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Develop High-Quality Peptidomimetics With Creative Proteomics’ b-Amino Acids Analysis Solutions

January 14
18:15 2020
With experienced scientists at Creative Proteomics, the company has developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of diverse polyols in different sample types.

ß-amino acid refers to an amino acid in which an amino group is bonded to a carbon atom at the ß position. The only common naturally occurring ß-amino acid is ß-alanine. Although ß-alanine is often used as a component of biologically active macromolecules, ß-peptides generally do not occur in nature. For this reason, ß-peptide antibiotics are being used to solve the problem of antibiotic resistance.

ß-Amino acid also offers promising opportunities to develop biologically active peptidomimetics, either employed alone or in conjunction with natural a-amino acids. Since it has great potential for unique conformational preferences that deviate considerably from a-peptide geometries, ß-amino acid can expand the possible chemistries and physical properties available to polyamide foldamers.

ß-amino acids are subdivided into ß2-, ß3- and ß2, 3-amino acids depending on the position of the side chain at the 3-aminopropionic acid core. In addition, cyclic amino acids have the amino group integrated in a ring, as is the case in ß-proline.

Many peptide drugs currently on the market are made by amide bond condensation using conventional natural amino acids. Natural amino acids are also called a-amino acids. This polypeptide can form a stable secondary structure through a-helix and ß-sheet, which can play a good role in regulating some enzymes in the human body. However, there are many proteases in the human body. Proteases often hydrolyze peptides, resulting in the metabolism of peptide drugs in the human body, shortening the half-life, increasing the cost of administration and the difficulty of administration.

After a long period of research by scientists, comparing peptides synthesized using ß-amino acids and a-amino acids, it was found that peptides synthesized using ß-amino acids (ß-peptide) also have good biological activity, good hydrolysis of proteases tolerability, and longer half-life. In the future, the use of ß amino acids as the backbone of peptide drugs will become a research hotspot.

With experienced scientists at Creative Proteomics, the company has developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of diverse polyols in different sample types, which can satisfy the needs of academic and industrial study in labs.

Its Platform

• LC-MS/MS

Solution Summary

• Identification and quantification of diverse polyols by LC-MS/MS.

Sample Requirement

• Normal Volume: 100ul plasma; 50mg tissue; 2e7 cells
• Minimal Volume: 50uL plasma; 30mg tissue; 5e6 cells

Solution Report

• A full report including all raw data, MS/MS instrument parameters and step-by-step calculations will be provided (Excel and PDF formats).
• Analytes are reported as µM or µg/mg (tissue), and CV’s are generally<10%.

About Creative Proteomics

Established in 2004, Creative Proteomics has gradually developed into an integrated company that provides proteomics, metabolomics, glycomics, and bioinformatics analysis services to researchers in the pharmaceutical, biotechnology, agriculture and nutrition industries, as well as academic and government organizations. With a continuing focus on quality, the company is proud of satisfying the needs of clients both at home and abroad covering more than 50 countries and districts.

Media Contact
Company Name: Creative Proteomics
Contact Person: Melisa George
Email: Send Email
Phone: 1-631-619-7922
Country: United States
Website: https://www.creative-proteomics.com